Researchers find that solve the method _'s treatment suffering from abdominal pain

Researchers find that solve the method _'s treatment suffering from abdominal pain

The new result of study reveals, the intestines function caused by employing the opium medicine or postoperative intestinal obstruction of the belly has already disorderlily no longer treated a great difficult problem on.

The 20th U.S.A. that held on the 19th - the 22nd of April, 2001 pains at association's scientific annual meeting, researchers have recommended reducing and postoperative measure in the skill of the incidence of postoperative intestinal obstruction, meanwhile, having also recommended a to be at new medicine which is studying stage, it is disorderly that this kind of medicine can relieve the intestines function that is being employed the opium medicine to cause for a long time.

The doctor of medicine Henrik Keblet says at the meeting, the function disorder of intestines caused by employing the opium medicine (are mainly show as the stomach empties the obstacle, the movements of large intestine and small intestine are limited and obstacle of defecating) It is the two kinds ofth disease that symptom caused by different reasons is similar with postoperative intestinal obstruction, in the report, he has reviewed and analyzed the cause of disease which causes the above-mentioned two kinds of states, and discussed the neural regulation mechanism of physiological mechanism and intestinal system of nerve of the opium medicine.

Dr. Keblet launched studying to this problem in term of treating surgery acute pain. In the clinical trial, researchers find, can reduce the emergence of the postoperative intestinal obstruction through taking the following measures:
Try hard to adopt and anaesthetize and replace general anesthesia outside the hard membrane; Anaesthetize for postoperative 48 hours outside some hard membrane, reduce even avoid employing the opium medicine (block on the second) all over ; Such as conditions permit, adopt the operation method of the peritoneoscope (because the operation wound of the peritoneoscope is little, thus can reduce the production of the endogenous inflammatory medium, and these inflammatory mediums are exactly materials causing intestinal movement ability to lower) ; Pull out nastal feed, in charge of as soon as possible while being postoperative, encourage patient begin, take food voluntarily as soon as possible while being postoperative, begin, eat, drink the water, contribute to intestinal the intersection of movement and recovery of ability in early days while being postoperative. Researchers call above-mentioned measure as " Shorten disorder patient's plan in hospital stays of the intestines function " ,Taking these measures, researchers find, a lot of patients can leave hospital in postoperative 48 hours, and pain and discomfort which these patients experience are all obviously relieved.

In another report, the doctor of medicine Marco Pappagallo, to constipation (OIC) caused by opium medicine Have discussed. He says: "OIC is a piece of QA and have brought to patient more uncomfortable. A lot of patients say to their doctor, they would rather not take the medicine relieving pain, because brought by constipation that the medicine relieving pain causes and uncomfortable makes people insufferable even more than pain. "

Dr. Pappagollo's research group is in order to confirm the incidence of OIC and the situation prevails to survey OIC patient. They find OIC take place more in old and schooling low and in the the intersection of weight and the intersection of index and high whole the intersection of health status and relatively poor white race. Compared with target of control group, OIC patient will often demonstrate various symptoms of this disease, need, use, rush down medicine slowly often.

Research reveals, OIC patient inclines to use the drug cocktail therapy composed of following medicines: Informal the intersection of forefront and alcohol, first the intersection of oxygen and the intersection of chlorine and general amine and food Suo, rice of application, compound and receive Lip river ketone. And OIC patient likes using the excrement and urine to soften pharmaceuticals and slow cathartic of irritation, but ordinary Americans like using fiber slow cathartic or slow cathartic of irritation while constipation takes place.

Researchers say: "Obviously, a lot of patients who take opium medicine are taking many kinds of therapeutic method, but the result is unsatisfactory. "

Have two researcher say some new medicine reversible to transfer to function disorderly by the intersection of opium and kinds of intestines that medicine bring in addition, and does not influence this kind of medicine to relieve the result of pain. Among them a researcher has offered the result of study about methylnaltrexone, methylnaltrexone is that a peripheral opium receptor resists pharmaceuticals short of moneyly. But another researcher has reported a new medicine ADL 8-2698, it is that the peripheral opium receptor resists pharmaceuticals short of moneyly.

12 hour use medicine, above-mentioned two reversible to it turns caused by opium medicine intestines to be function disorderly medicine. These two kinds of medicines are both at clinical trial stage at present, under test, these two kinds of medicines have not demonstrated the side effect, have not reduced the result that the opium medicine relieves pain either.

In addition, it study also reveal,it can also reduce 8-2698 of ADLs because postoperative employ by opium kinds of medicine and intestinal obstruction that be caused.

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