Discover that brings out the molecule of depression to chronic inflammation

Discover that brings out the molecule of depression to chronic inflammation
The researchers of University of Illinois of American say, a kind of IDO enzyme correlated to depression and can be found in whole bodying, in fact play an essential role in initiating depression in chronic inflammation. It is here to just issue>This research on the network edition of the magazine has defined IDO (indole amine 2, 3 - pair adds oxygen enzyme) for the first time Some chronic inflammation initiates the molecular switch of depression. In these decades, the doctors have understood for a long time the patient who suffer from chronic inflammation such as coronary heart disease, rheumatoid and arthritis is apter to have a depression than other people. Some medicines used for treating hepatitis C and malignant melanin tumour, such as - interferon, also can initiate depression on a considerable amount of diseases.
In this new research, researchers expose the little mouse to Bacillus Calmette-Guerin (BCG) China, Bacillus Calmette-Guerin is a lot of local vaccine for preventing the tuberculosis in the world. BCG can produce slight chronic inflammation on little mouse, can pass and measure a certain immune system albumen (inflammation cell factor) in blood and brain Value measure .
The little mouse that exposes to BCG demonstrates normal disease such as losing the appetite, activity is reduced, but after these symptoms disappear, the little mouse will still continue demonstrating that is similar to the depressed behavior. Recover, come over in disease, BCG these infect little mouse, infect little mouse to be more passive than those either in the face of emergency. Researchers say, after putting them for several minutes in a barrel of water, though they have physical power of escaping, seldom escape voluntarily, takes more time to float on the surface of water passively. Researchers still find, once resist the depressed medicine for these little mice, their depressed disease will disappear.
Researchers think, it can initiate immune cells to produce the cell factor to infect, cell factor to help the intersection of human body and letter infected to resist make albumen. These albumens can activate IDO in the body and brain, IDO degradative tryptophane too, metabolite that mankind and animal are behavioral to exert an influence. Past research has already found, increase and depressed symptom of these metabolites have strong relevance on some patients.
Analyze to the genetic adjustment of the little mouse brain that shows, exposed to the expression that will increase IDO and two kinds of inducible IDO cell factors in BCG, these two kinds of cell factors are tumour necrosis - Factor and - Interferon.
Because IDO degradative tryptophane, and tryptophane is that one kind can produce the chemical material on influence of positive mood in the brain, so the scientists infer, it is caused by plain reduction of serum in the brain that depression appears in chronic inflammatory disease. However, have denied this conjecture to little depressed mouse's plain horizontal checking of serum in the brain. Researchers claim, the brain can remedy the reduction of tryptophane.
In order to prove whether IDO depressed behavior to the little mouse is essential, researchers feed the medicine that the food can inhibit IDO to the little mouse, and test again. Little symptom of mouse just like before this, carry on IDO inhibit little mouse pretreated from develop, produce depressed behavior. The little mouse that IDO gene lacks has not demonstrated the depressed behavior exposed to BCG little normal mouse at all.
Researchers suspect, metabolite that IDO produced while degrading tryptophane has promoted depression to a certain extent. The report emphasizes, perhaps IDO will become an important target resisting the depressed medicine and researching and developing at the same time.
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