Discover that it causes the heart to decline _'s general knowledge to exchange the fault in pressure signal

Discover that it causes the heart to decline _'s general knowledge to exchange the fault in pressure signal
Researcher of the medical center Maier finds, the genetic mutation is to lead to the fact the cardiac presents the reason why the heart declines, because making a variation will produce a kind of unusual protein, it is unable to discern the pressure signal from body.
This is that a researcher find these proteins can not discern the pressure alarm for the first time. Its result is that they can't be to usually controlling the suggesting regulating and making a response of the pressure in the heart. This kind of defect makes the cardiac muscle very easy to damage. Their research report is issued on magazine of latest a " natural science of heredity ".
Research person in charge, Andre and Qi Qi in Tyre of physiologic expert of heart say this discovery has a initiative one, because it has announced that can bring the heart and decline the key molecular mechanism of the new treatment. "We knew little about the tolerance ability of the pressure to the heart in healthy and ill condition in the past. This discovery has opened up the new field for the medical research of cardiovascular vessel, because we have untied the heart weak reason to pressure tolerance. "
This research has treble meaning: First, decline the heart to regard as the pressure of heart cell and adjust and control exchanges or signal questions appeared in the mechanism for the first time; Second, have carried on the experiment on the human body; Third, convincing evidence indicate, the exchange fault of the pressure signal causes the heart to be tired and apt and declines.
Great majority let heart decline research of reason, think heart decline control the intersection of protein and defect in the mechanism of heartbeat cause from gene, have not expected the pressure adjusts and controls the transmission route of the mechanism.
Researchers have chosen some patients declining unidentified reason heart, have carried on the overall genetic inspection to DNA in their blood specimen. Found finally, a certain gene which formed pressure reacting protein of some patients' was all defective. Find after this kind of variation which causes the defect, researchers have reproduced this kind of variation in the laboratory with the genetic recombinant technique, in order to observe the mutant molecule result.
They find, this kind of variation will cause one kind in heart cell to call " potassium passway sensitive to ATP " Key structure abnormal state. In the healthy human body, this potassium passway is coordinating the equilibrium of potassium and calcium in the blood flow of heart. Calcium is that the heart shrinks to need. And a certain amount of potassium can make cells resume the weighing apparatus of level after each heartbeat, and limit the inflow in cells of calcium. Too much calcium will damage the cell tissue and cause the heart to decline. The new discovery shows, " potassium passway sensitive to ATP " Can play a role in defending the protective screen, if they present the defect, can't perceive the pressure state of the body correctly. When this kind of situation takes place, they are unable to discern that coordinate the supersession signal of potassium and calcium flow.
From theory, researchers can apply this discovery to other hearts' declining patients, look for, control key electricity react while being other or pressure that machinery react reflect protein. Qi Qi in Tyre says, the final goal is to find better heart disease therapeutic method.
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