Discover : Circulate tumour cells and have " L Surge and pour into by oneself " R Ability

Discover : Circulate tumour cells and have " L Surge and pour into by oneself " R Ability
Cancer develops and is usually considered to be one and send the course that tumour is being shifted constantly originally, and U.S.A. scientist one discovers newly, circulate tumour cells, break away from, send tumour and travel get the intersection of body and other cancer cell of position originally, can return their take place tumour and continue, develop, thus strengthen tumour and grow. This course is called " L Surge and pour into by oneself " (seed oneself) . Researchers claim this discovery contributes to the development of the new target tropism cancer therapeutic method. It is here that the relevant research results are issued December 25 >On the magazine .
This the first author, U.S.A.s of research thesis New York Kate Lin cancer centre cancer biology and researcher MiYong Jin at department of the Chinese Academy of Scienceses hereditary Slone ( Transliteration) Claim, their research has not merely announced that pour into this phenomenon and mechanism defying, have also announced its function that may be produced in development of tumour.
Experiment that researcher carry on on little mouse show, defy and inject into and involve two different functions by oneself: First, tumour attracts it circulate products, namely the ability to circulate tumour cell by oneself; Second, circulate tumour cells and attract the ability of tumour that the infiltration gets again to have in order to respond to tumour. Researchers have confirmed 4 kinds of genes that is responsible for carrying out these functions: IL-6, IL 8, FSCN1 and MMP1. Among them IL-6 and IL-8 are responsible for attracting and circulating some cells that have invading nature in the tumour cell group most, and FSCN1 and MMP1 responsible for cell the infiltration is gone on and regulated and then to circulate tumour.
Study to reveal, circulating breast cancer cells has gene expression mode similar to the aforesaid, breast cancer cells can be spread to the lung, skeleton and brain, therefore has increased the probability that tumour transfers to these organs. Will take place and pour into the phenomenon defying in the cancer cell of other types too besides breast cancer, including cancer of colon and melanin tumour.
Researchers think this discovery is very important . Slone - claim by the intersection of Kate and the intersection of Lin and the intersection of cancer and the intersection of centre and the intersection of cancer and biology with hereditary agate of President Joan ancient angstroms of Dr. Sa of department of the Chinese Academy of Sciences, this discovery offers a good chance, contribute to developing the new target tropism therapeutic method, slow down even prevent tumour progress by intervening surging and pouring into the course.
Associate professor of treatment Dr. Larry and Naughton of the breast cancer department of this centre points out, defy the discovery of pouring into the phenomenon to offer the new visual angle for clinical observation in the cancer treatment by oneself. The doctors all know the size of tumour and quality of prognosis have relation. People usually think great tumour will release more shifting the cancer cell of potentiality, thus lead to the fact the prognostic result is relatively bad. But this kind may to defy, pour into, lead to the fact by oneself cancer cell of invading etc. in fact, have also promoted the growth of some tumour and carried the transformation of tumour far in similar mechanism. (Liu HaiYing )
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