Member's mark _'s general knowledge of discovering cancer of the esophagus is relevant

Member's mark _'s general knowledge of discovering cancer of the esophagus is relevant
Live in the sending area of the height of cancer of the esophagus too, eat the same food, drink the same water, why some people suffer from cancer of the esophagus, but are some people safe and sound? Led by institute of oncology of Chinese Academy of Medical Sciences the countries concerned just finished " The Ninth Five-Year Plan " The scientific and technological brainstorm subject has found the answer to the question from the molecule level: Carry the intersection of cl/cl and genotype and the intersection of GSTM1 and gene, lack person of genotype, suffer from cancer of the esophagus than person who does not carry 8 times more with high risk. The research and for make the intersection of target and preventing from tactics offer scientific basis clear for expound the intersection of cancer of the esophagus and cause of disease further.
Cancer of the esophagus is one of the most common malignant tumour in our country, nearly 250,000 new patients emerge every year. The clinic of cancer of the esophagus although makes progress while treating, the result is still depressing, survival rate is less than 10% in 5, so, it is the focal point that cancer of the esophagus will be studied in the 21st century to prevent from having illness coming on. At present, think both at home and abroad, economic, effective and practical cancer prevents from depending on " individual " Prevent, and should make sure the individual prevent, must understand who is apter to suffer from cancer of the esophagus. Lin DongXin Professor, Chinese Academy of Medical Sciences of institute of oncology lead seminar, have studied risky individual carcinogen supersession gene many attitude and many attitude apt to be perceptual influence to cancer of the esophagus of gene related to the fact that DNA damages and repairs of cancer of the esophagus of our country emphatically, and make the important result. They pass the bigger sample (more than 2200) Case controlled study,last more than 10 pieces, there are carcinogen supersession and DNAs, find the intersection of carcinogen and the intersection of supersession and the intersection of cl/cl and genotype and the intersection of GSTM1 and gene of gene, CYP2E1 of enzyme, that Rsal discern it lacks genotypes to be whether heredity, Chinese of cancer of the esophagus exchange the sense factor, these two genes have obvious cooperative effect, the risk that the person who carries these two kinds of genotypes suffers from cancer of the esophagus is 8 times higher than that of the person who is not carried. Expression and activity level of liver CYP2E1 enzyme of their persons who have also studied 3 kinds of different CYP2E1 genotypes, find its activity horizontal cl/cl genotype gt; C1/c2 or c2/c2 genotype, has expounded many attitudes of CYP2E1 gene influence the biological mechanism of the risk of cancer of the esophagus. Already the magazine has published at home and abroad most of above-mentioned result of study, and the majority is the domestic and foreign first report.
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