Carcinogenic mechanism of arsenic

Carcinogenic mechanism of arsenic
A large amount of epidemiology make investigations, reveal inorganic arsenic expose lung cancer, skin carcinoma, the intersection of bladder and cancer and emergence, kidney of cancer in people, there is reaction relation of dosage. In view of the above, the international cancer research institution confirmed inorganic arsenic as human carcinogen formally in 1980.
However, arsenic carcinogenic epidemiology materials and animal experimental result are not totally identical, the carcinogenic animal experimental model of arsenic has not been set up yet so far, the carcinogenic mechanism of arsenic is not yet very clear so far. Some recent research shows, arsenic may have tumour to urge the long activity, inferior arsenic acid can stimulate the release of epidermis angle protein cell growth factor and promote the abnormal state of epidermis angle protein cells to proliferate.
Animal's experiment discovers, after offering the carcinogenic initial thing, two methyl arsine acid can obviously promote the emergence of big mouse's bladder, liver, kidney and thyroid gland cancer, and offer two methyl arsine acid group not to observe the emergence of tumour alone. Two methyl arsine acid of this suggestion may be that one kind urge the cancer thing. We recent research find inferior the intersection of arsenic and acid and the intersection of arsenic and acid can inhibit the intersection of V79 and supersession cooperative effect of cell obviously too, may connect communication (GJIC) to the chink of cell to brief on inorganic arsenic There is inhibitory activity. It is very important that the growth of GJIC to cell is adjusted and controlled, it is an important characteristic of tumour cells that its function is unusual, the ones that take place with cancer urge long stage and is closely related with.
Recent finding, inferior arsenic acid and arsenic acid can obviously inhibit hamster's lung from becoming fibrous V79 cellular metabolism cooperative effect, can inhibit cells GJIC to brief on inorganic arsenic. Study, adopt the intersection of cell and the intersection of scratch and the intersection of dyestuffs and mark, show the intersection of track and technology, prove inorganic arsenic have inhibitory activity as fibrous cells GJIC to people's skin further. Therefore, influence GJIC to be acting on the characteristic commonly to different cells of inorganic arsenic. It can make canceration cells break away from the control of normal cells around and present independent hyperplasia that GJIC is unusual, develop into tumour finally.
It is not clear at present that arsenic influences the mechanism of cells GJIC, studies have suggested, a lot of urge the function on cells GJIC of the cancer thing to relate to the fact that they activate the chink that PKC relies on to connect phosphorylation of albumen. Discover, inferior arsenic acid and people's skin of different density become fibrous cell function 24 hours later, it is active to promote cell membrane and afterbirth thick liquid PKC notably, the activation to afterbirth membrane protein kinase of cell is particularly prominent. PKC is usually by not having active form to exist in the thick liquid of afterbirth, it can transfer to biomembrane from the thick liquid of afterbirth after activation, it is essential condition the most of the biological information transmission. So, we infer inferior arsenic acid may be passed and activated the protein kinase activity of cell, and cause the chink of cell to connect phosphorylation of albumen and cause GJIC to inhibit and initiate the canceration finally.
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