Nitre acyl base anion declines the beneficial _'s treatment in treating the heart

Nitre acyl base anion declines the beneficial _'s treatment in treating the heart
According to the research report of " PNAS " which researchers published on April 14 this year, the nitrous oxides will produce nitre acyl base anion after removing an electron. In the heart of the dogs declines animal's model, uses shrink and relaxation ability that nitre acyl base anion can strengthen the cardiac muscle. Researchers explain, after using nitre acyl base anion for the healthy dog, can increase its cardiac output, the intravenous relaxation result of the alternative emerges, will not imitate the single function of oxidizing nitrogen. But it is not so obvious at present that the heart whether nitre acyl base anion declines to the heart has similar function. In order to clarify this, David Kass from John and Hopkin Sri Lankan medical college,et al. has studied pharmacology and physiology of nitre acyl with anionic base in the congestive dog animal's model in heart failure Study function. In this kind of animal's model, nitre acyl base anion reduces preload and after-load of the heart notably, have strengthened the shrink function of the heart greatly. The nitrous oxides can even reduce preload and after-load of the heart, strengthen the relaxation rate of the heart. But react in only front of myocardium contractile force that nitre acyl base anion can exert an influence. Researchers point out, nitre acyl base anion can also strengthen the heart and can react to decline the Epinephrine of the heart, but react and does not depend on 's Epinephrine can be amazing in front of myocardium contractile force that nitre acyl base anion causes. Kass tells reporter of Reuter: " such mutant nitrous oxides (remove an electron) Will cause the pharmacology function completely different from nitrate medicine. Especially have special prospects to the treatment that the heart declines. " He is saying to the above-mentioned discovery while summarizing: "The main difference among nitre acyl base anion and nitrate medicine or NO lies in its impact on front of myocardium contractile force, similar to heart and normal heart result that the heart declines. receptor can not inhibit this kind from acting on to block pharmaceuticals. Nitre acyl base anionic impact on front of myocardium contractile force and receptor block pharmaceuticals and have cooperative effect. " Researchers think, the pharmacology function of nitre acyl with anionic base is unique. Kass adds: "We are testing a stronger, more pure nitre acyl base anion compound, the such as Angelis salt compound that we used can't serve as clinical medicine in the past. We have already found a drug candidate at present, its chemical constitution is changed to some extent, this kind of compound not only can take orally for a long time, the intravenous infusion that also can meet an urgent need. "
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